Protein name:
Integrator complex subunit 3 (Int3) ;
Alternative:
Sensor of single-strand DNA complex subunit A (SOSS-A;Sensor of ssDNA subunit A) ;SOSS complex subunit A ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12. Component of the SOSS complex, composed of SOSS-B (SOSS-B1/OBFC2B or SOSS-B2/OBFC2A), SOSS-A/INTS3 and SOSS-C/SSBIP1. SOSS complexes containing SOSS-B1/OBFC2B are more abundant than complexes containing SOSS-B2/OBFC2A. Interacts with SOSS-B1/OBFC2B, SOSS-B2/OBFC2A and SOSS-C/SSBIP1; the interaction is direct. Interacts with NBN/NBS1.
Function:
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites.
Subcellular Location:
Nucleus
Localizes to nuclear foci following DNA damage.
Protein Attributes:
50:
MELQKGKGTV | AAAASGAAGG | GGGGAGAGAP | GGGRLLLSTS | LDAKDELEER |
100:
LERCMSIVTS | MTAGVSEREA | NDALNAYVCK | GPPQHEEICL | GLFTLVLTEP |
150:
AQAQKCYRDL | ALVSRDGMNI | VLNKINQLLM | EKYLKLQDTC | RTQLVWLVRE |
200:
LVKSGVLGAD | GVCMTFMKQI | AGGDVTAKNI | WLAESVLDIL | TEQREWVLKS |
250:
SILIAMAVYT | YLRLIVDHHG | TAQLQTLRQK | EVDFCISLLR | ERFMECLMIG |
300:
RDLVRLLQNV | ARIPEFELLW | KDIIHNPQAL | SPQFTGILQL | LQSRTSRKFL |
350:
ACRLTPDMET | KLLFMTSRVR | FGQQKRYQDW | FQRQYLSTPD | SQSLRCDLIR |
400:
YICGVVHPSN | EVLSSDILPR | WAIIGWLLTT | CTSNVAASNA | KLALFYDWLF |
450:
FSPEKDSIMN | IEPAILVMHH | SMKPHPAITA | TLLDFMCRII | PNFYPPLEGH |
500:
VRQGVFSSLN | HIVEKRVLAH | LAPLFDNPKL | DKELRSMLRE | KFPEFCSSPS |
550:
PPVEVKIEEP | VSMEMDNHLS | DKDESCYDNA | EAAFSDDEED | LNSKGKKREF |
600:
RFHPIKETVV | EEPVDVTPYL | DQLDESLRDK | VLQLQKGSDT | EAQCEVMQEI |
650:
VDQVLEEDFD | SEQLSVLASC | LQELFKAHFR | GEVLPEEVTE | ESLEESVGKP |
700:
LYLIFRNLCQ | MQEDNSSFSL | LLDLLSELYQ | KQPKIGYHLL | YYLRASKAAA |
750:
GKMNLYESFA | QATQLGDLHT | CLMMDMKACQ | EDDVRLLCHL | TPSIYTEFPD |
800:
ETLRSGELLN | MIVAVIDSAQ | LQELVCHVMM | GNLVMFRKDS | VLNILIQSLD |
850:
WETFEQYCAW | QLFLAHNIPL | ETIIPILQHL | KYKEHPEALS | CLLLQLRREK |
900:
PSEEMVKMVL | SRPCHPDDQF | TTSILRHWCM | KHDELLAEHI | KALLIKNNSL |
950:
PRKRQSLRSS | SSKLAQLTLE | QILEHLDNLR | LNLANTKQNF | FSQTPILQAL |
1000:
QHVQASCDEA | HKMKFSDLFS | LAEEYEDSST | KPPKSRRKAA | LSSPRSRKNA |
1041:
TQPPNAEEES | GSSSASEEED | TKPKPTKRKR | KGSSAVGSDS | D
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Polyclonal Antibody for Mouse Int3
Polyclonal Antibody for Mouse Int3
Monoclonal Antibody for Mouse Int3
Monoclonal Antibody for Mouse Int3
R&D Technical Data
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Precision
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Recovery
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Linearity
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 460-1041 (ISOFORM 1)
strain :
C57BL/6J .
tissue :
Cerebellum .
tissue :
Thymus .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain :
C57BL/6 .
strain :
Czech II .
tissue :
Brain .
tissue :
Mammary tumor .